Impact of Bioimmuno with methisoprinol on non-specific cellular and humoral defense mechanisms and resistance of African catfish (Clarias gariepinus) to experimental infection with iridovirus         [RESEARCH ARTICLE]

  • Barbara Kazuń
  • Andrzej K. Siwicki
Keywords: Bioimmuno, isoprinosine, immune system, fish


The aim of the experiment was to determine the impact Bioimmuno had on the non-specific cellular and humoral defense mechanisms and resistance to experimental infection with iridovirus of African catfish, Clarias gariepinus (Burchell). The experiment was performed on clinically healthy African catfish weighing from 30 to 200 g. The fish were infected experimentally with iridovirus 59.90 at a dose of 104 TCID50 ml-1. Bioimmuno administered at a dose of 1 kg per 50 kg of feed most effectively stimulated the responses of non-specific cellular and humoral defense mechanisms, corrected delayed immunological reactions induced by iridovirus infection, and limited mortality caused by experimental viral infection of 5-45%.


B. Kazuń [+], A.K. Siwicki
Department of Fish Pathology and Immunology
Inland Fisheries Institute in Olsztyn
Główna 48, 05-500 Żabieniec, Poland
Tel. +48 227562490, e-mail: